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Physiological effects

Nitrates produce a rapid high that resembles alcohol intoxication. Within minutes of inhaling, the user experiences intoxication along with other effects similar to those produced by alcohol. If sufficient amounts are inhaled they produce anesthesia, a loss of sensation, and even unconsciousness. [2] Some users may also experience the impression of time slowing down. [3] Alcohol-like effects include slurred speech, muscle weakness, belligerence, apathy, impaired judgment, euphoria, and dizziness. In addition, users may experience lightheadedness, hallucinations, and delusions. Successive inhalations may make users feel less inhibited and less in control. After using inhalants heavily, abusers may feel drowsy for several hours and experience a lingering headache. [4]

Nitrates also cause a giddy feeling and a pounding of the heart and as they also dilate the pupil, the black part of the eye, they can cause distortions in vision. Some use nitrates for anal intercourse because they relax the anus muscles, and sex in general as they can make you feel less inhibited, increase skin sensitivity and produce a sense of exhilaration and acceleration before orgasm.

When inhaled, alkyl nitrites (amyl, butyl, isopropyl, etc.) act as vasodilators, relaxing smooth muscles throughout the body, including the sphincter muscles of the anus and the vagina. The blood vessel dilation causes a sudden drop followed by a sharp spike in systemic blood pressure, increases heart rate, and produces a sensation of heat and excitement that can last for several minutes. The blood vessels in the brain lack sheaths of smooth muscle and are unique in that they expand and contract in order to regulate blood pressure within the brain. The alkyl nitrites override this regulatory mechanism, and as such the drop in systemic blood pressure and subsequent vascular pressure spike are experienced directly by the brain. This causes the euphoric head rush.

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